Methadone block of K+ current in squid giant fiber lobe neurons.
نویسندگان
چکیده
منابع مشابه
Methadone block of K+ current in squid giant fiber lobe neurons
Voltage-dependent ionic currents were recorded from squid giant fiber lobe neurons using the whole-cell patch-clamp technique. When applied to the bathing solution, methadone was found to block IK, I Na and I Ca. Both I Na and I Ca were reduced without apparent change in kinetics and exhibited IC(50)'s of 50-100 and 250-500 mu M, respectively, at +10 mV. In contrast, IK was reduced in a time-de...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1996
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.107.2.243